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Rachel Shemesh

Global retinoblastoma survival and globe preservation: a systematic review and meta-analysis of associations with socioeconomic and health-care factors

Author: Rachel Shemesh
Year of publication: 2022
Journal:

This systematic review and meta-analysis investigates trends in global retinoblastoma survival and globe preservation during the past 40 years. The review included 314 studies, 38 130 patients from 80 regions globally presenting during 1980–2020. 255 articles were entered for time-trend meta-analysis, covering 29 106 patients from 73 countries. Both overall survival (from 79% [95% CI 74–84] to 88% [83–93]; p=0·017) and globe salvage rate (from 22% [14–32] to 44% [36–52]; p=0·0003) improved significantly over the four decades. Wide disparities were observed between higher-income and lower-income countries. Overall survival, globe salvage, and globe salvage for advanced intraocular disease correlated positively with income level. Higher overall survival was associated with lower Gini index (p=0·0001) and with populations that had smaller percentages living in rural areas (p=0·0005). Higher globe salvage was associated with better health-care financing and accessibility (p=0·030). Overall survival (p=0·0024) and globe salvage (p=0·022) were both associated positively with education level. Survival gaps were observed in sub-Saharan Africa and southeast and southwest Asia. In conclusion, retinoblastoma treatment outcomes have improved globally over the past four decades but large disparities persist between higher-income and lower-income countries, with some areas having major survival gaps. Targeted health-care policy making with increased health-care financing and accessibility are needed in low-income and lower-middle-income countries to improve retinoblastoma outcomes worldwide.

Link to the paper on PubMed: https://pubmed.ncbi.nlm.nih.gov/35093202/

From the Publications Archives

Published 26/03/22
Ametconsectetur: Rachel Shemesh
Tags:

This systematic review and meta-analysis investigates trends in global retinoblastoma survival and globe preservation during the past 40 years. The review included 314 studies, 38 130 patients from 80 regions globally presenting during 1980–2020. 255 articles were entered for time-trend meta-analysis,…

Published 1/01/22
Ametconsectetur: Rachel Shemesh
Tags:

 In this prospective study of 692 patients from 11 retinoblastoma (RB) centres, Kaliki et al. studied the effect of lag time between onset of symptoms and diagnosis of RB in these countries based on their national income and analyzed its…

Published 31/07/21
Ametconsectetur: Rachel Shemesh
Tags: Eye

  This is a cross-sectional analysis including 4351 treatment-naive retinoblastoma patients from 153 countries. The goal of the study was to investigate whether sex predilection exists for this childhood eye cancer. For the entire sample, the mean retinoblastoma sex ratio,…

Published 29/03/21
Ametconsectetur: Rachel Shemesh
Tags: Cancer Epidemiology

This is a prospective study documenting a series of children with RB treated at Ruharo Eye Centre between December 2009 and November 2019. Survival by stage of RB, number of eyes affected, and visual acuity were assessed. The study found…